Role of Continuous Glucose Monitoring in Non-Insulin-Requiring Type 2 Diabetes


  • Ronnie Aronson, MD, FRCPC Chief Medical Officer, LMC Diabetes & Endocrinology


Effective management of diabetes has always been contingent on our awareness of patients’ glucose levels. There has been a slow evolution in glucose-measurement technology over the last century. Benedict’s copper reagent test for urinary glucose became available in 1908, followed by the colorimetric technology of Dextrostix, patented in 1963 by Miles Laboratories Inc., and the electrochemical process of ExacTech introduced by Medisense in 1987, as examples. 

Continuous glucose monitoring (CGM) systems have evolved more rapidly with a well-established evidence base documenting their value in individuals using insulin. Their potential impact among individuals with type 2 diabetes (T2D) who are not using insulin has been the subject of a series of studies in the past few years, culminating most recently in a key Canadian randomized controlled trial, the IMMEDIATE study.

Author Biography

Ronnie Aronson, MD, FRCPC, Chief Medical Officer, LMC Diabetes & Endocrinology

Ronnie Aronson is an Endocrinologist and the founder of LMC Diabetes and Endocrinology (LMC), a practice groups of more than 60 Endocrinologists, providing care to over 45,000 people with diabetes, supported by diabetes educators, pharmacists, chiropodists and optometrists. Dr. Aronson’s own research focus has centred on individuals who struggle to achieve optimal diabetes health outcomes. He has led projects that have defined their barriers, validated new devices, and developed novel tools and strategies to overcome these barriers. He has served as Principal Investigator in over 300 clinical trials in diabetes and its complications. 


Aronson R, Brown R, Chu L, et al. IMpact of flash glucose Monitoring in pEople with type 2 Diabetes Inadequately controlled with non-insulin Antihyperglycaemic ThErapy (IMMEDIATE): A randomized controlled trial. DOM. 2023 April; 25(4):1024–1031.

Yoo HJ, An Hg, Park SY, et al. Use of a real time continuous glucose monitoring system as a motivational device for poorly controlled type 2 diabetes. Diabetes Res Clin Pract. 2008 Oct;82(1):73–9.

Cosson E, Hamo-Tchatchouang E, Dufaitre-Patouraux L, et al. Multicentre, randomised, controlled study of the impact of continuous sub-cutaneous glucose monitoring (GlucoDay) on glycaemic control in type 1 and type 2 diabetes patients. Diabetes Metab. 2009 Sep;35(4):312–8.

Vigersky RA, Fonda SJ, Chellappa M, et al. Short- and longterm effects of real-time continuous glucose monitoring in patients with type 2 diabetes. Diabetes Care. 2012 Jan;35(1):32–8.

Bergenstal RM, Mullen DM, Strock E, et al. Randomizedcomparison of self-monitored blood glucose (BGM) versus continuous glucose monitoring (CGM) data to optimize glucose control in type 2 diabetes. J Diabetes Complications. 2022 Mar;36(3):108106.

Cox DJ, Banton T, Moncrief M, et al. Minimizing glucose excursions (GEM) with continuous glucose monitoring in type 2 diabetes: A randomized clinical trial. J Endocr Soc. 2020 Aug 18;4(11):bvaa118.

Price DA, Deng Q, Kipnes M, Beck SE. Episodic real-time CGM use in adults with type 2 diabetes: Results of a pilot randomized controlled trial. Diabetes Ther. 2021 Jul;12(7):2089–2099.

Moon SJ, Kim K, Lee WJ, et al. Efficacy of intermittent shortterm use of a real-time continuous glucose monitoring system in non-insulin-treated patients with type 2 diabetes: A randomized controlled trial. Diabetes Obes Metab. 2023 Jan;25(1):110–120.

Choe HJ, Rhee E, Won JC, et al. Effects of patient-driven lifestyle modification using intermittently scanned continuous glucose monitoring in patients with type 2 diabetes: Results from the randomized open-label PDF study. Diabetes Care. 2022 Oct 1;45(10):2224–2230.

Wada E, Onoue T, Kobayashi T, et al. Flash glucose monitoring helps achieve better glycemic control than conventional self-monitoring of blood glucose in non-insulin-treated type 2 diabetes: a randomized controlled trial. BMJ Open Diabetes Res Care. 2020 Jun;8(1):e001115.

Polonsky WH, Fortmann AL, Soriano E, et al. The AH-HA! Project: Transforming group diabetes self-management education through the addition of flash glucose monitoring. Diabetes Technol Ther. 2023 Mar;25(3):194–200.

Seidu S, Kunutsor SK, Ajjan RA, Choudhary P. Efficacy and safety of continuous glucose monitoring and intermittently scanned continuous glucose monitoring in patients with type 2 diabetes: A systematic review and meta-analysis of interventional evidence. Diabetes Care. 2024 Jan;47(1):169–179.

Ferreira ROM, Trevisan T, Pasqualotto E, et al. Continuous glucose monitoring systems in non-insulin-treated people with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Diabetes Technol Ther. 2023 Dec 13.doi:10.1089/dia.2023.0390. Online ahead of print.




How to Cite

Aronson, R. (2024). Role of Continuous Glucose Monitoring in Non-Insulin-Requiring Type 2 Diabetes. Canadian Diabetes & Endocrinology Today, 2(1), 11–15. Retrieved from