Risk Stratification to Improve Care and Outcomes in Diabetic Kidney Disease


  • Navdeep Tangri, MD, PhD Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba Chronic Disease Innovation Centre, Seven Oaks General Hospital, Winnipeg, Manitoba


Chronic kidney disease (CKD) is a global public health problem that affects one in eight Canadians, and nearly one in two with Type 2 diabetes (T2DM). It is widely recognized as a potent risk factor for cardiovascular (CV) outcomes, all-cause mortality, and progression to kidney failure requiring dialysis or transplant. End stage kidney disease is catastrophic for patients and families, but for most individuals who are identified as having high-risk CKD, progression is now preventable in this new era of guideline-directed medical therapy. 

This review will summarize a new paradigm for diagnosis, staging, and management of CKD, that is centered around risk of progression rather than kidney function (eGFR or serum creatinine alone). We will describe the heterogeneity in the progression of kidney disease, as well as the clinical utility and usability of accurate risk prediction tools that can be used today in Canadian clinical practice. 

Author Biography

Navdeep Tangri, MD, PhD, Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba Chronic Disease Innovation Centre, Seven Oaks General Hospital, Winnipeg, Manitoba

Dr. Navdeep Tangri, MD, PhD, is working on a clinical research program that is also translational, focusing on the improvement of clinical decision making for patients with advanced chronic kidney disease. He developed and validated the Kidney Failure Risk Equation (KFRE) to predict the need for dialysis in patients with chronic kidney disease, and is currently engaged in multiple validation and implementation exercises to increase the uptake of the KFRE. 


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How to Cite

Tangri, N. (2024). Risk Stratification to Improve Care and Outcomes in Diabetic Kidney Disease. Canadian Diabetes & Endocrinology Today, 2(1), 5–10. Retrieved from https://CanadianDiabetesAndEndocrinologyToday.com/article/view/2-1-Tangri