Addressing Metabolic Dysfunction‑Associated Steatotic Liver Disease (MASLD) in Endocrinology settings in Canada: From Prevalence to Patient‑Centred Management
DOI:
https://doi.org/10.58931/cdet.2025.3s0144Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent in Canadian endocrinology, affecting up to 70% of those with type 2 diabetes and 75% with obesity. Despite this, routine screening is rare, leading to missed detection and intervention. Advanced fibrosis, observed in 15% of cases, increases the risk of liver and cardiovascular complications. This article addresses the burden of MASLD and the need for systemic screening and patient-centred care to improve outcomes and reduce Canada’s disease burden.
References
Kim J, Raggi P, Carreau AM, Wharton S, Cheng AYY, Swain MG. A review of multidisciplinary care in metabolic dysfunction-associated steatohepatitis and cardiometabolic disease, with a focus on Canada. Diabetes Obes Metab. Published online September 12, 2025. doi: 10.1111/dom.70117.
Diabetes Canada Clinical Practice Guidelines Expert Working Group:, Kim J, Bajaj HS, Ramji A, Bemeur C, Sebastiani G. Diabetes and metabolic dysfunction-associated steatotic liver disease in adults: a clinical practice guideline. Can J Diabetes. 2025;49(4):222-236. doi: 10.1016/j.jcjd.2025.04.003
Targher G, Valenti L, Byrne CD. Metabolic dysfunction-associated steatotic liver disease. N Engl J Med. 2025;393(7):683-698. doi: 10.1056/NEJMra2412865
Cusi K, Abdelmalek MF, Apovian CM, Balapattabi K, Bannuru RR, Barb D, et al. Metabolic dysfunction-associated steatotic liver disease (MASLD) in people with diabetes: the need for screening and early intervention. A Consensus Report of the American Diabetes Association. Diabetes Care. 2025;48(7):1057-1082. doi: 10.2337/dci24-0094
Horn P, Tacke F. Key takeaways from the updated multidisciplinary European MASLD guidelines. eGastroenterology. 2025;3(2):e100196. Published 2025 Jun 8. doi: 10.1136/egastro-2025-100196
Mahmoud MC, Abdelmalek MF. The liver in diabetes and metabolic syndrome. Clin Liver Dis. 2025;29(3):407-429. doi: 10.1016/j.cld.2025.04.003
Younossi ZM, Zelber-Sagi S, Lazarus JV, Wong VW, Yilmaz Y, Duseja A, et al. Global consensus recommendations for metabolic dysfunction-associated steatotic liver disease and steatohepatitis. Gastroenterology. 2025;169(5):1017-1032.e2. doi: 10.1053/j.gastro.2025.02.044
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Canadian Diabetes & Endocrinology Today

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.