Type 2 Diabetes Remission: An Overview

Authors

  • Akshay Jain, MD, FRCPC, FACE, CCD, ECNU, DABOM Division of Endocrinology, Department of Medicine, University of British Columbia; TLC Diabetes and Endocrinology, Surrey, BC

DOI:

https://doi.org/10.58931/cdet.2023.117

Abstract

In my practice, one of the most common questions I encounter with my type 2 diabetes (T2D) patients is, “How can I get rid of this disease?” The primary focus of practitioners’ discussion regarding T2D is the chronicity and irreversibility of the condition. Recently, however, new hope is emerging concerning remission of diabetes with the increasing amount of evidence-based data available.

Author Biography

Akshay Jain, MD, FRCPC, FACE, CCD, ECNU, DABOM, Division of Endocrinology, Department of Medicine, University of British Columbia; TLC Diabetes and Endocrinology, Surrey, BC

Dr. Akshay Jain is the first Canadian physician to be triple board-certified by the American Boards in Endocrinology, Internal Medicine and Obesity Medicine. He is the only Canadian to have won the AACE Rising Star in Endocrinology Award (2022) and to feature on Medscape’s list of 25 Top Rising Stars of Medicine (2020). He practices in Surrey, BC and is a Clinical Instructor in the Division of Endocrinology at the University of British Columbia. He is fluent in 6 languages: English, Hindi, Gujarati, Marathi, Marwari and Urdu. In 2022, he won the Top 25 Canadian Immigrant Award.

References

International Diabetes Federation. IDF diabetes atlas. 10th edition. Brussels: International Diabetes Federation. 2021. [accessed 2022 May 22]. https://www.diabetesatlas.org.

Wang H, Naghavi M, Allen C, et al. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388(10053):1459-1544. DOI: https://doi.org/10.1016/S0140-6736(16)31012-1

Spencer Bonilla G, Rodriguez-Gutierrez R, Montori VM. What we don’t talk about when we talk about preventing type 2 diabetes-addressing socioeconomic disadvantage. JAMA Intern Med 2016;176(8):1053-1054. DOI: https://doi.org/10.1001/jamainternmed.2016.2952

Canadian Diabetes Cost Model. Ottawa: Diabetes Canada; 2016.

MacKay D, Chan C, Dasgupta K, Dominy C, Gagner M, Jin S, et al. Diabetes Canada Clinical Practice Guidelines Steering Committee: Remission of Type 2 Diabetes: Diabetes Canada Clinical Practice Guidelines Expert Working Group. Can J Diabetes. 2022 Dec;46(8):753-761. DOI: https://doi.org/10.1016/j.jcjd.2022.10.009

UKPDS Group. U.K. Prospective Diabetes Study 16. Overview of 6 years’ therapy of type II diabetes: a progressive disease. Diabetes 1995;44(11):1249-1258. DOI: https://doi.org/10.2337/diabetes.44.11.1249

Wysham C, Shubrook J. Beta-cell failure in type 2 diabetes: mechanisms, markers, and clinical implications. Postgrad Med 2020;132(8):676-686. DOI: https://doi.org/10.1080/00325481.2020.1771047

Albaugh VL, Axelrod C, Belmont KP, Kirwan JP. Physiology reconfigured: how does bariatric surgery lead to diabetes remission? Endocrinol Metab Clin North Am. 2023 Mar;52(1):49-64. DOI: https://doi.org/10.1016/j.ecl.2022.06.003

Eisenberg D, Shikora SA, Aarts E, Aminian A, Angrisani L, Cohen RV, et al. 2022 American Society for Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO): Indications for Metabolic and Bariatric Surgery. Surg Obes Relat Dis. 2022 Dec;18(12):1345-1356. DOI: https://doi.org/10.1016/j.soard.2022.08.013

Lean MEJ, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, et al. Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster randomised trial. Lancet Diabetes Endocrinol 2019;7(5):344e55. DOI: https://doi.org/10.1016/S2213-8587(19)30068-3

Hillier TA, Pedula KL. Characteristics of an adult population with newly diagnosed type 2 diabetes: the relation of obesity and age of onset. Diabetes Care. 2001 Sep;24(9):1522-1527. DOI: https://doi.org/10.2337/diacare.24.9.1522

Wharton S, Lau DCW, Vallis M, Sharma AM, Biertho L, Campbell-Scherer D, et al. Obesity in adults: a clinical practice guideline. CMAJ. 2020 Aug 4;192(31):E875-E891. DOI: https://doi.org/10.1503/cmaj.191707

Published

2023-03-20

How to Cite

Jain, A. (2023). Type 2 Diabetes Remission: An Overview. Canadian Diabetes & Endocrinology Today, 1(1), 17–20. https://doi.org/10.58931/cdet.2023.117

Issue

Section

Articles